Table 1.

Domains of the RE-AIM framework.

Domain	Definition	Assessment level	Operationalization within study
Reach	The absolute number, proportion, and representativeness of individuals who are willing to participate in a given initiative	Individual level	•Number of patients referred to program •Number of patients accepting to participate in the program •Characteristics of participating patients
Effectiveness	The impact of an intervention on important outcomes, including potential negative effects, quality of life, and economic outcomes	Individual level	Percentage of patients with positive clinical outcomes pre and post program
Adoption	The absolute number, proportion, and representativeness of settings and intervention agents who are willing to initiate a program	Organization level	•The proportion of HCPs following the enhanced PR program out of the total HCPs involved in PR at the study site •Characteristics of HCPs involved in PR at study site
Implementation	At the setting level, implementation refers to the intervention agents’ fidelity to the various elements of an intervention’s protocol. This includes consistency of delivery as intended and the time and cost of the intervention	Organization level	•Fidelity on content and delivery of the group education sessions by the HCPs involved •Changes to the program and reasons
Maintenance	At the individual level, maintenance has been defined as the long-term effects of a program on outcomes after 6 or more months after the most recent intervention contact	Individual level	Percentage of patients with positive clinical outcomes at 3-month follow-up
	The extent to which a program or policy becomes institutionalized or part of the routine organizational practices and policies	Organization level	•Reach as described above within new PR cycles 18 months after initial implementation of the program •Effectiveness as described above within new PR cycles 18 months after initial implementation of the program •Adoption: changes to PR staff •Implementation as described above within new PR cycles 18 months after initial implementation of the program + fidelity to exercise recommendations

Available from www.re-aim.org.