Table 2.
Interactive effect of UA and HDL-C for MACE and mortality.
| Parameter | MACE HR (95% CI) | P value | Death HR (95% CI) | P value |
|---|---|---|---|---|
| Low UA high HDL-C | 1 (Reference) | 1 (Reference) | ||
| High UA high HDL-C | 3.52 (1.78,6.96) | < 0.001 | 2.20 (0.72,6.77) | 0.169 |
| Low UA low HDL-C | 3.23 (1.75,5.98) | < 0.001 | 2.34 (0.87,6.33) | 0.094 |
| High UA low HDL-C | 10.68 (5.54,20.61) | < 0.001 | 6.39 (2.43,16.79) | < 0.001 |
| Additive Interaction | ||||
| SI | 2.04 (1.07,3.88) | < 0.05 | 2.12 (0.67,6.73) | >0.05 |
| AP | 0.46 (0.16,0.76) | < 0.05 | 0.45 (−0.02,0.91) | > 0.05 |
| REPI | 4.93 (−0.37,10.22) | >0.05 | 2.84 (−1.38,7.07) | >0.05 |
| Multiplicative Interaction | ||||
| 0.90 (0.38,2.16) | 0.814 | 1.21 (0.31,4.71) | 0.786 | |
Values are presented with Hazard ratios and 95% confidence intervals. P < 0.05 indicated statistical significance.
UA, uric acid; HDL-C, high-density lipoprotein cholesterol; MACE, major adverse cardiovascular events; CI, confidence interval; RERI, relative excess risk to interaction; AP, attributable proportion; SI, synergy index.