Figure 6.

Examples illustrating prioritized drug target genes through network diffusion

(A) Top 10 network neighbors of drug target APP (brown circle) and their prioritization values (i.e., normalized node probabilities) by the eQTL-GWAS method for Alzheimer’s disease are shown before ($r=1$) and after diffusion ($r=0.6$) on the STRING network.

(B) Same representation as in (A) showing Exome prioritization values for psoriasis and tumor necrosis factor (TNF) drug target.

(C) Top 10 network neighbors of drug target F2 (coagulation factor II, thrombin) in the STRING, CoXRNAseq, and FAVA networks. GWAS prioritization values for venous thromboembolism (VTE) are shown before ($r=1$) and after diffusion ($r=0.6$) on each network. In each network example (A–C), the drug target gene was among the top 1% prioritized genes only after diffusion at $r=0.6$.