TABLE 3.

The primary pharmacokinetic parameters of macitentan in two groups of rats. (n = 6, mean ± SD).

Parameters	Control group	Experimental group
AUC(0-t) (μg/L*h)	7,873.97 ± 1,384.98	20,263.67 ± 6,427.63*
AUC(0-∞) (μg/L*h)	7,897.83 ± 1,369.87	20,378.31 ± 6,442.74*
MRT(0-t) (h)	5.48 ± 0.96	5.91 ± 0.74
MRT(0-∞) (h)	5.60 ± 1.08	6.12 ± 0.80
t1/2z (h)	4.53 ± 0.90	5.07 ± 1.15
Tmax (h)	1.92 ± 0.80	2.50 ± 0.55
CLz/F (L/h/kg)	2.60 ± 0.48	1.07 ± 0.36*
Cmax (μg/L)	1,339.44 ± 518.24	2,999.69 ± 1,428.35*

Notes: *Significantly different from control, p < 0.05.