TABLE 4.

The primary pharmacokinetic parameters of ACT-132577 in two groups of rats. (n = 6, mean ± SD).

Parameters	Control group	Experimental group
AUC(0-t) (μg/L*h)	93,689.35 ± 9,770.34	107,185.45 ± 22,066.22
AUC(0-∞) (μg/L*h)	95,982.33 ± 9,790.28	108,373.12 ± 21,125.06
MRT(0-t) (h)	11.26 ± 1.40	10.34 ± 1.43
MRT(0-∞) (h)	12.06 ± 1.81	10.78 ± 1.97
t1/2z (h)	5.97 ± 1.09	5.18 ± 1.30
Tmax (h)	7.33 ± 2.73	6.33 ± 1.51
CLz/F (L/h/kg)	0.21 ± 0.02	0.19 ± 0.04
Cmax (μg/L)	5,695.69 ± 1,631.05	7,741.50 ± 2,615.93

Notes: *Significantly different from control, p < 0.05.