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. 2023 Jul 10;14:1215694. doi: 10.3389/fphar.2023.1215694

FIGURE 5.

FIGURE 5

Degradation of conjugate 2 (A) and release of the free MMAE as metabolite (B) in rat liver lysosomal homogenate over 72 h. Extracted Ion Chromatograms of the conjugate 2 (t R = 14.4 min) and MMAE (t R = 12.3 min) (C).