Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Molecular Mechanisms of cGAS-STING in Inflammaging. After binding with cytoplasmic dsDNA, cGAS catalyzes the synthesis of cGAMP, which is an active ligand of STING. Activation of STING results in the upregulation of autophagy and the expression of inflammatory factors, which in turn leads to SASP. Furthermore, the cGAS-STING pathway indirectly promotes cell cycle arrest.
