Table 2.

STING inhibitors in the development process.

Drug Name	Category	Mechanism of action	REF
C-178 C-176 C170, C-171	Nitrofurans	Binds to Cys91 of STING and prevents palmitoylation	(184)
H-151	Indole derivatives	Binds to Cys91 of STING and prevents palmitoylation	(184)
SN-011	Multisubstituted benzamides	Specific binding within the 2'3'-cGAMP conjugation pocket of STING protein	(185)
Astin C	Cyclopeptides	Directly regulates STING signaling vesicles and binds to the C-terminal structural domain of STING	(186)
degrader 55	PROTACs	connecting the sting inhibitor C-170 to a ligand for E3 ligase CRBN through an alkyl linker	(187)