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Climbing fiber synaptic pathology in ET. (A) In a control subject, climbing fiber synapses, as visualized by the vesicular glutamate transporter type 2 immunohistochemistry, usually do not extend to the outer 20% of the molecular layer (dash line), which is the parallel fiber synaptic territory. (B) In a ET patient, climbing fiber synapses abnormally extend to the parallel fiber synaptic territory (arrows).
