Table I.
Demographic and anthropometric characteristics, Epworth sleepiness scale, polysomnography parameters and SXB dose during follow-ups.
| Follow-up1 n = 23 Mean (SD) | Follow-up2 n = 16 Mean (SD) | Follow-up3 n = 10 Mean (SD) | p value FU-1 versus FU-2 | p value FU-1 versus FU-3 | |
|---|---|---|---|---|---|
| Age (years) | 42.2 (13.75) | 42.38 (13.95) | 44.2 (16.01) | NS | NS |
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| Sex (m/f) | 13/10 | 8/8 | 5/5 | – | – |
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| BMI kg/m2 | 28.61 (5.19) | 27.21 (5.9) | 26.4 (6.01) | NS | NS |
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| SXB dose (g) | 4.5 (1.15) | 5.25 (1.62) | 5.47 (0.86) | NS | NS |
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| Epworth | 17.67 (7.5) | 18 (7) | 20.5 (4.9) | NS | NS |
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| Sleep efficiency (%) | 78.57 (13.17) | 78.99 (8.64) | 78.92 (8.68) | NS | NS |
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| Sleep latency (min) | 8.02 (5.68) | 8.65 (7.95) | 6.5 (3.35) | NS | NS |
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| REM sleep latency (min) | 33.17 (48.01) | 33.31 (48.01) | 35.06 (50.34) | NS | NS |
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| TST (min) | 382.63 (55.16) | 377.96 (52.25) | 384.9 (46.52) | NS | NS |
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| WASO (min) | 90.75 (59.81) | 95.37 (41.52) | 102.25 (40.4) | NS | NS |
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| Awakenings/hour (n.º/h) | 17.68 (12.11) | 15.93 (10.74) | 12.3 (4.39) | NS | NS |
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| Stage N1 (minutos) | 68.26 (28.39) | 78.12 (54.97) | 104.5 (80.49) | NS | 0.03a |
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| Stage N1 (%) | 17.61 (7.09) | 17.39 (10.24) | 21.37 (16.48) | ||
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| Stage N2 (minutos) | 136.674 (52.01) | 150.37 (48.41) | 148.45 (52.72) | 0.03a | NS |
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| Stage N2 (%) | 33.84 (9.5) | 35.01 (10.89) | 30.32 (10.5) | ||
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| Stage N3 (minutos) | 102.02 (54.64) | 87.78 (48.1) | 89.65 (55.59) | NS | NS |
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| Stage N3 (%) | 26.39 (13.74) | 21.11 (12.61) | 18.48 (11.7) | ||
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| Stage REM (minutos) | 50.95 (16.65) | 50.87 (20.04) | 42.35 (19.77) | NS | NS |
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| Stage REM (%) | 13.09 (4.58) | 11.68 (4.09) | 8.66 (3.93) | ||
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| AHI (Median, IQR) | 2.65 (0-9.6) | 2.8 (0-6.6) | 4.05 (3.1-19) | NS | 0a |
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| PLMI (Median, IQR) | 0 (0-7.3) | 17.65 (3.6-27.22) | 19.35 (15.2-31.4) | 0.01a | 0.04a |
AHI: apnea-hypopnea index; BMI: body mass index; IQR: interquartile range; NS: not significant; PLMI: periodic leg movement index; PSG: polysomnography; REM: rapid eye movements; SXB: sodium oxybate; TST: total sleep time; WASO: wake after sleep onset.
a
Significant differences at p < 0.05.