TABLE 1.
Overview of the different cell types, complexity levels, exposure scenarios and endpoints addressed by the various partners of the NGTxC project. A = acute, R = repeat.
| Partner | Cell/Tissue models | 2D/3D | Treatment | Endpoints | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genomic instability | Proliferation | Cytotoxicity | Oxidative stress | NR-activation | Migration | Phenotypic changes | Inflammation | Epigenetic changes | ||||
| ANSES | Liver | 2D/3D | A/R | • | • | • | • | • | • | • | ||
| BfR | Breast, Liver, Colon | 2D | A/R | • | • | • | • | • | ||||
| INRAE | Multicellular liver | 3D | A/R | • | • | • | • | • | • | |||
| INSERM | Breast, Adipocytes | 2D/co-culture | A | • | • | • | • | |||||
| IRFMN | NA | NA | NA | • | • | |||||||
| NIB | Liver | 3D | R | • | • | • | • | • | • | • | ||
| NILU | Breast | 2D/3D | A | • | • | • | • | |||||
| RECETOX | Liver | 2D | A | • | • | |||||||
| RIVM | Zebrafish | NA | A/R | • | • | |||||||
| RPTU | Colon | 2D | A/R | • | • | • | • | • | ||||
| UL-LACDR | Breast, Liver | 2D | A | • | • | • | • | • | • | • | ||
| UNAV | Liver | 2D/3D | A/R | • | • | • | ||||||
ANSES: french agency for food, Environmental and Occupational Health and Safety, BfR: german federal institute for risk assessment, INRAE: national research institute for agriculture, Food and the Environment, France INSERM: national institute for health and medical research, France, IRFMN: istituto di ricerche farmacologiche mario negri, Italy, NIB: national institute of biology, Slovenia, NILU, the climate and environmental research institute, Health Effects Laboratory, RECETOX: research centre for toxic compounds in the environment czech republic, RIVM: national institute for public health and the environment, the Netherlands, RPTU: Rheinland-Pfälzische Technische Universität, Germany, UL-LACDR: leiden academic centre for drug research, the Netherlands, UNAV: University of Navarra, Spain.