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. 2023 Jul 10;13:1239593. doi: 10.3389/fcimb.2023.1239593

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Copyright © 2023 Zhu, Zhang, Dong, Song and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adhesion molecules is required for anti-fungal response. (A) WT mice and mice deficient for CD11b, CD11a and ICAM-1 were infected with 10⁵ C. albicans, their survival curve was evaluated. (B) Mice with or without infection with 10⁶ C. albicans for 8h were euthanized, the recruitment of neutrophils (CD45⁺CD11b⁺Ly6G⁺) in the kidney was analyzed by flowcytometry. Note the y axis for CD11b mice is side scatter instead of CD11b due to knockout of this gene. (C) The statistics of neutrophil percentage out of total leukocytes (CD45⁺ cells, n=4). *, p<0.05; **, p<0.01 by student’s t test.