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. 2023 Jul 10;14:1173728. doi: 10.3389/fimmu.2023.1173728

Figure 1.

Figure 1

Effect of P4 on human T cells and cancer cell lines. (A) Peripheral blood mononuclear cells (PBMCs) were stimulated with toxic shock syndrome toxin 1 in the presence of 0, 2, 20, and 200 μM of P4. T cell activation was analyzed using flow cytometry. Upper panels: CD4+ T cells; lower panels: CD8+ T cells. The levels of activated CD25+/PD-1+ T cells are shown. (B) JEG-3, BeWo, MDA-MB-231, HEK-293, and Karpas 707H cells cultured with P4 (left panels) or cortisol (right panels). Solid black lines: 0 μM; broken black lines: 2 μM; solid gray lines: 20 μM; broken gray lines: 200 μM. Data are presented as the mean ± standard deviation of three independent experiments. P4, progesterone.