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. 2023 Jul 10;14:1173728. doi: 10.3389/fimmu.2023.1173728

Figure 6.

Figure 6

Profile of human lymphocytes in the spleen of tumor-bearing humanized mise. (A) Typical patterns of human lymphocytes in the NOG-hIL-4-Tg mouse spleen. Cells were gated as shown in Supplementary Figure S1 . The gated fractions are shown above each panel. Vertical and horizontal lines represent the markers analyzed using flow cytometry. (B) Box-and-whisker plots of lymphocyte subsets. *P < 0.05; **P < 0.01 (one-way analysis of variance or Student’s t-test) (PBS [n = 11], ATZ [n = 9], Lipo-P4 [n = 7], Lipo-Emp [n = 3]). ATZ [A], atezolizumab; Lipo-Emp, empty liposome; Lipo-anti-PD-L1-P4 (Lipo-P4), liposome-encapsulated anti-programmed death ligand 1 antibody-conjugated P4; MA, MDA-MB-231 cells transplanted with atezolizumab; ME, MDA-MB-231 cells transplanted with Lipo-Emp; ML, MDA-MB-231 cells transplanted with Lipo-anti-PD-L1-P4; MP, MDA-MB-231 cells transplanted with PBS; PBS [P], phosphate-buffered saline.