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. 2023 Jul 10;14:1173728. doi: 10.3389/fimmu.2023.1173728

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Copyright © 2023 Kametani, Ito, Ohshima, Manabe, Ohno, Shimizu, Yamada, Katano, Kirigaya, Ito, Matsumoto, Tsuda, Kashiwagi, Goto, Yasuda, Maeki, Tokeshi, Seki, Fukase, Mikami, Ando, Ishimoto and Shiina

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profiles of spleen and bone marrow lymphocytes of tumor-bearing humanized NOG-hIL-4-Tg mice. The proportions (%) of human CD45+ cells/lymphocyte gated-cells, CD19+/CD45+ cells, CD3+/CD45+ cells, CD4+/CD3+ cells, and CD8+/CD3+ cells in the spleen (horizontal lines) and bone marrow (vertical lines) of NOG-hIL-4-Tg mice are plotted. Approximate straight lines and correlation coefficients are shown (PBS [n = 8], ATZ [n = 6], Lipo-P4 [n = 6]). ATZ, atezolizumab; Lipo-P4, liposome-encapsulated anti-programmed death ligand 1 antibody-conjugated P4; PBS, phosphate-buffered saline. Lower two panels of Lipo-P4 present the same graphs shown in the upper panels, but the vertical axis was expanded. Correlation lines and correlation coefficients (R²) are shown in the panels.