Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 10;14:1197275. doi: 10.3389/fimmu.2023.1197275

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 He, Zhang, Gong, Gu, Dong, Pang, Zhang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Analysis of the relationship between hub genes and the disease genes. (A) Differential analysis of disease regulatory genes. The regulatory genes of HLA-B, MIF, PSTPIP and TLR1 were significantly upregulated in RA compared to the normal control groups. (*p < 0.05 was considered significantly different **p < 0.01, ***p < 0.001, ns, no significance). (B) The correlation analysis of the hub genes and the differential regulatory genes. The first plot shows that GRN was significantly positively correlated with HLA-B. The second pot visualizes the Pearson correlation between hub genes and differential regulatory genes. The third plot shows PTGS2 was significantly positively correlated with MIF. The Pearson coefficients and p-values are shown at the top of the plots (p < 0.01 indicates significant correlation).