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. 2023 Jul 10;14:1197275. doi: 10.3389/fimmu.2023.1197275

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Copyright © 2023 He, Zhang, Gong, Gu, Dong, Pang, Zhang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSEA analysis of hub genes. (A) The top 3 most enriched pathways about function enrichment of PTGS2 gene: Nod-like receptor signaling pathway, gene set enriched in FcγR mediated phagocytosis, gene set enriched in the Chemokine signaling pathway. (B) The top 3 most enriched pathways about function enrichment of GRN gene: Lysosome, Leishmania infection, B cell receptor signaling pathway. (C) The top 3 most enriched pathways about function enrichment of ENO1 gene: Lysosome, Pathogenic Escherichia coli infection, Leishmania infection. Screening criteria for significant gene sets included adj. p-value < 0.05 and FDR < 0.5. NES, normalized enrichment score.