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. 2023 Jul 10;14:1197275. doi: 10.3389/fimmu.2023.1197275

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Copyright © 2023 He, Zhang, Gong, Gu, Dong, Pang, Zhang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis for transcription factors of hub genes (A) Histogram of the AUC. By calculating the AUC, the over-representation of each motif for hub genes was assessed. Red vertical line indicates the degree of significance, whereby motifs with AUC higher than the significance level are considered significant motifs. (B) The recovery curve for the three most significant motifs. Red line represents the global mean of recovered motif curve, green line represents the mean ± standard deviation. Motifs that were larger than the mean ± standard deviation were considered statistically significant. Blue line represents the current motif’s recovered curve. The motif cisbp_M5493 was significantly enriched in hub genes (ENO1 and PTGS2).