Table 1.
Demographic and Clinical Characteristics and Differences between Cognitive Phenotypes
| Cluster 1 n=97 | Cluster 2 n=46 | Cluster 3 n=73 | Cluster 4 n=56 | Cluster 5 n=116 | Test | Eta2 | |
|---|---|---|---|---|---|---|---|
| Age: M (SD) | 50.4 (15.0)b | 45.8 (17.8) | 44.8 (16.5) | 43.9 (16.1) | 43.9 (14.6)a | F=2.8* | .03 |
| Sex: n (%) | χ2=9.53* | .02 | |||||
| Male | 77 (79.4%) | 43 (93.5%) | 56 (76.7%) | 42 (75%) | 83 (71.6%) | ||
| Female | 20 (20.6%)a | 3 (6.5%)b | 17 (23.3%)a | 14 (25%)a | 33 (28.4%)a | ||
| Race: n (%) | χ2=52.6** | .06 | |||||
| Multi-racial | 0 (%) | 1 (2.2%) | 3 (4.1%) | 0 (%) | 1 (.9%) | ||
| American Indian | 1 (1.0%) | 0 (%) | 0 (%) | 0 (%) | 0 (%) | ||
| Asian | 1 (1.0%) | 0 (%) | 0 (%) | 0 (%) | 0 (%) | ||
| Black | 47 (48.5%) | 29 (63%) | 46 (63%) | 47 (83.9%) | 96 (82.8%) | ||
| White | 48 (49.5%) | 16 (34.8%) | 23 (31.5%) | 9 (16.1%) | 19 (16.4%) | ||
| Other | 0 (%) | 0 (%) | 1 (1.4%) | 0 (%) | 0 (%) | ||
| Education: M (SD) | 14.2 (2.5)b | 13.6 (2.5) | 13.3 (2.6) | 12 (2.1)a | 12.4 (2.1)a | F=11.7** | .11 |
| HIV Disease | |||||||
| Duration of HIV Infection | 167 (124) | 195 (102) | 139 (110) | 170 (119) | 161 (98) | F=.68 | .01 |
| Undetectable viral load (<50 copies/ml), % | 86 (90%)a | 33 (81%) | 57 (80%) | 33 (65%)b | 86 (76%)b | χ2=13.6** | .04 |
| Current CD4 count, median (IQR) | 556 (407) | 541 (316) | 556 (362) | 563 (446) | 492 (354) | F=1.07 | .01 |
| Nadir CD4 count, median (IQR) | 196 (327) | 185 (270) | 219 (299) | 174 (325) | 222 (301) | F=.49 | .007 |
| Health Comorbidities | |||||||
| Affective BDI-II Subscale Score: M (SD) | 4.8 (5.8)b | 3.1 (2.9)b | 5.6 (7) | 6.5 (7.3) | 7.8 (7.2)a | F=4.3** | .05 |
| Hepatitis-C Positive: n (%) | 6 (6.2%) | 6 (13%) | 7 (9.6%) | 5 (8.9%) | 9 (7.8%) | χ2=.72 | .005 |
| Substance Use KSMK Lifetime: M (SD) | |||||||
| Tobacco Total Score | 6 (5.1) | 6.9 (4.9) | 7.8 (4.2) | 7.2 (4.6) | 7 (5.0) | F=1.6 | .018 |
| Alcohol Total Score | 7.2 (3.9) | 7.8 (3.9) | 7.2 (4.2) | 7.1 (4.1) | 6 (4.3) | F=1.3 | .021 |
| Marijuana Total Score | 5.1 (4.2) | 5.1 (3.7) | 5.3 (3.7) | 6.2 (5) | 6.4 (4.6) | F=.68 | .019 |
| Cocaine Total Score | 2.9 (4.7) | 3 (4.9) | 3.4 (5.4) | 3.3 (5.3) | 3.1 (5.2) | F=.11 | .002 |
| Opiates Total Score | .14 (.92) | .25 (.75) | .11 (.50) | .33 (1.3) | .54 (1.9) | F=1.4 | .019 |
All values are reported as z scores. Descriptive statistics are reported in favor of full statistical test results in order to focus on clinically meaningful (i.e., Z-score < −1) results
M Mean, SD Standard Deviation