Table 4.
Multivariable analyses of survival
| Unadjusted Cox regression | Adjusted Cox regression | |||
|---|---|---|---|---|
| HR | P | HR | P | |
| Complete mesocolic excision | ||||
| Stages I–III | 0.78 (0.59, 1.03) | 0.081 | 0.81 (0.60, 1.10) | 0.176 |
| Stage I | 0.87 (0.52, 1.47) | 0.608 | 0.85 (0.49, 1.48) | 0.566 |
| Stage II | 0.92 (0.55, 1.54) | 0.746 | 1.13 (0.65, 1.95) | 0.667 |
| Stage III | 0.61 (0.39, 0.95) | 0.031 | 0.52 (0.31, 0.85) | 0.010 |
| Complete mesocolic excision (DFS*) | ||||
| Stages I–III | 0.83 (0.63, 1.08) | 0.164 | 0.86 (0.65, 1.15) | 0.306 |
| Stage I | 0.88 (0.53, 1.47) | 0.631 | 0.88 (0.51, 1.52) | 0.654 |
| Stage II | 0.91 (0.55, 1.49) | 0.711 | 1.09 (0.65, 1.82) | 0.752 |
| Stage III | 0.75 (0.50, 1.13) | 0.167 | 0.66 (0.42, 1.03) | 0.068 |
| Mesocolic plane (continuous variable) | ||||
| Stages I–III | 1.01 (0.99, 1.04) | 0.441 | 1.00 (0.97, 1.03) | 0.867 |
| Stage I | 1.04 (0.99, 1.08) | 0.114 | 0.99 (0.52, 1.87) | 0.970 |
| Stage II | 1.03 (0.98, 1.07) | 0.181 | 0.73 (0.40, 1.31) | 0.291 |
| Stage III | 0.97 (0.93, 1.01) | 0.179 | 0.53 (0.32, 0.88) | 0.015 |
| Mesocolic plane (using prespecified cut-off) | ||||
| Stages I–II | 1.26 (0.91, 1.73) | 0.164 | 1.15 (0.82, 1.63) | 0.418 |
| Stage I | 1.45 (0.78, 2.69) | 0.237 | 1.41 (0.75. 2.68) | 0.289 |
| Stage II | 1.41 (0.78, 2.54) | 0.262 | 1.23 (0.65, 2.31) | 0.533 |
| Stage III | 1.04 (0.63, 1.69) | 0.889 | 0.95 (0.55. 1.64) | 0.862 |
Values in parentheses are 95% confidence intervals. Results are shown for overall survival unless otherwise indicated. *For disease-free survival (DFS) see main text. Adjustments were made for the following variables: BMI, age, centre, T category, tumour location, ASA grade, and operative approach.