Table 1.
Local manifestations before propensity score matching
| Parameter | Supportive only | Intervention |
|---|---|---|
| Patients, n | 208 | 217 |
| Age (years), median (i.q.r.) | 65 (57–71) | 67 (62–72) |
| Co-morbidity* | ||
| ASA I | 28 (13.5) | 14 (6.5) |
| ASA II | 125 (60.1) | 113 (52.1) |
| ASA ≥III | 54 (26.0) | 88 (40.6) |
| Performance status* | ||
| ECOG 0 | 99 (47.6) | 90 (41.5) |
| ECOG 1 | 62 (29.8) | 68 (31.3) |
| ECOG ≥2 | 16 (7.7) | 13 (6.0) |
| Resection type* | ||
| TTO-CA | 79 (38.0) | 73 (33.6) |
| TTO-IA | 57 (27.4) | 110 (50.7) |
| THO-CA | 71 (34.1) | 34 (15.7) |
| POD of diagnosis, median (i.q.r.) | 7 (6–9) | 7 (6–10) |
| Level of care* | ||
| Surgical ward | 153 (73.6) | 132 (60.8) |
| ICU/HC/MC/PACU | 43 (20.7) | 73 (33.6) |
| ED/other | 9 (4.3) | 10 (4.6) |
| Leucocyte count (×109/L), median (i.q.r.) | 10.5 (8.3–13.7) | 11.9 (9.1–15.4) |
| qSOFA score, median (i.q.r.) | 0 (0–0) | 0 (0–1) |
| Respiratory failure | 9 (4.3) | 33 (15.2) |
| Haemodynamic failure | 1 (0.5) | 10 (4.6) |
| Renal failure | 4 (1.9) | 10 (4.6) |
| Defect circumference ≥25% | 9 (4.3) | 22 (10.1) |
| Primary treatment | ||
| Primary strategy | ||
| Supportive only | 208 (100.0) | 0 (0.0) |
| Drainage | 0 (0.0) | 142 (65.4) |
| Defect closure | 0 (0.0) | 19 (8.8) |
| Drainage and defect closure | 0 (0.0) | 56 (25.8) |
| Feeding intervention | 25 (12.0) | 32 (15.7) |
| Endoscopic drainage | 0 (0.0) | 50 (23.0) |
| Stent placement | 0 (0.0) | 47 (21.7) |
| EVAC | 0 (0.0) | 16 (7.4) |
| Reoperation | 3 (1.4) | 51 (23.5) |
| ICU/HC/MC readmission | 11 (5.3) | 61 (28.1) |
| Secondary treatment | ||
| Need for secondary treatment | 78 (37.5) | 123 (56.7) |
| Secondary strategy | ||
| Supportive only | 52 (25.0) | 50 (23.0) |
| Drainage | 7 (3.4) | 23 (10.6) |
| Defect closure | 12 (5.8) | 19 (8.8) |
| Drainage and defect closure | 4 (1.9) | 25 (11.5) |
| Missing | 2 (1.0) | 2 (0.9) |
| Stent placement | 15 (7.2) | 28 (12.9) |
| EVAC | 0 (0.0) | 9 (4.1) |
| Reoperation | 7 (3.4) | 24 (11.1) |
| ICU/HC/MC readmission | 9 (4.3) | 21 (9.7) |
| Outcomes | ||
| 90-day mortality | 9 (4.3) | 23 (10.6) |
| LOS, hospital (days), median (i.q.r.) | 20 (15–28) | 28 (20–42) |
| LOS, ICU (days), median (i.q.r.) | 2 (1–5) | 5 (2–12) |
| Healing time (days), median (i.q.r.) | 19 (10–29) | 21.50 (9–37) |
| CCI, median (i.q.r.) | 31 (21–50) | 43 (32–65) |
Values are n (%) unless otherwise indicated. *Percentages may not add up to 100% due to missing data. i.q.r., interquartile range; ECOG, Eastern Collaborative Oncology Group; TTO, transthoracic oesophagectomy; CA, cervical anastomosis; IA, intrathoracic anastomosis; THO, transhiatal oesophagectomy; POD, postoperative day; HC, high care; MC, medium care; PACU, post-anaesthesia care unit; ED, emergency department; qSOFA, quick sequential organ failure assessment; EVAC, endoscopic vacuum-assisted closure; LOS, length of stay; CCI, comprehensive complication index.