Table 5.
Secondary efficacy analyses adjusted
| Intervention (n = 681) |
Control (n = 663) |
Adjusted GEE model† | Unadjusted GEE model‡ | Comparison between groups§ | ||||
|---|---|---|---|---|---|---|---|---|
| LS mean/OR* | P | LS mean/OR* | P | Difference* | P | |||
| Duration of hospital stay (days) | ||||||||
| ȃMean(s.d.) | 10.2(13.3) | 11.9(13.0) | LS mean −1.90 (−3.27, −0.53) | 0.007 | LS mean 1.71 (−3.12, −0.30) | 0.0172 | −1.71 (−3.13, −0.31) | 0.017 |
| ȃMedian (range) | 7 (0–175.6) | 7.5 (0.1–112.9) | ||||||
| ICU care | 133 (19.5) | 145 (21.9) | OR 1.19 (0.88, 1.60) | 0.26 | OR 1.15 (0.89, 1.50) | 0.29 | 2.3 (−2.1, 6.8) | 0.32 |
| Duration of ICU care (days) | n = 133 | n = 145 | ||||||
| ȃMean(s.d.) | 3.12(5.97) | 5.40(8.34) | LS mean −2.35 (−4.07, −0.64) | 0.007 | LS mean −2.28 (−4.00, −0.57) | 0.009 | −2.28 (−4.01, −0.59) | 0.006 |
| ȃMedian (range) | 1.29 (0.02–53.54) | 2.15 (0.03– 62.02) | ||||||
| Readmission to ICU | 22 (3.2) | 30 (4.5) | OR 1.62 (0.90, 2.91) | 0.11 | OR 1.42 (0.81, 2.49) | 0.22 | 1.3 (−0.9, 3.5) | 0.28 |
| Surgical complications (Clavien–Dindo classification) | LS mean −0.16 (−0.23, −0.09) | <0.001 | LS mean −0.15 (−0.22, −0.08) | <0.001 | <0.001 | |||
| ȃNo complications | 1 (0.1) | 7 (1.1) | ||||||
| ȃGrade I–IIIa | 494 (72.5) | 407 (61.4) | ||||||
| ȃGrade IIIb–IVb | 115 (16.9) | 141 (21.3) | ||||||
| ȃGrade V | 71 (10.4) | 108 (16.3) | ||||||
Values are n (%) unless otherwise indicated; *values in parentheses are 95% confidence intervals. †Analysed by GENMOD (General Mode) with GEE model, with binary outcome and link function logit adjusted for age, intestinal ischaemia, faecal, purulent/other peritonitis, chronic obstructive lung disease, ischaemic heart disease, congestive heart failure, chronic renal failure, diabetes, obesity, smoking, ASA grade, and sex. ‡Analysed by GENMOD with GEE model, with binary outcome and link function logit. §For dichotomous variables, the confidence interval is the asymptotic Wald confidence limits with continuity correction; analysis by Fisher’s exact test (lowest 1-sided P value multiplied by 2). LS (Least Squares), .