Table 5.
Subgroup and meta-regression analysis for rate difference (concordance – reverse concordance)
| Subgroup analysis | Meta-regression analysis | |||
|---|---|---|---|---|
| Rate difference | P | Coefficient b | P | |
| Probe | ||||
| ȃSentimag® | −0.002 (−0.009, 0.004) | 0.502 | ||
| ȃTokyo probe | −0.004 (−0.084, 0.076) | 0.922 | ||
| SPIO | ||||
| ȃFerucarbutran | −0.004 (−0.084, 0.076) | 0.922 | ||
| ȃMagtrace® | −0.010 (−0.022, 0.001) | 0.078 | ||
| ȃSienna+® | −0.004 (−0.021, 0.013) | 0.642 | ||
| Injection site | ||||
| ȃPeritumoral | −0.120 (−0.020, 0.063) | 0.099 | ||
| ȃSubareolar | 0.001 (−0.006, 0.007) | 0.846 | ||
| Timing of injection | −0.0558 (−0.0904, −0.0212)* | 0.002 | ||
| ȃPreoperative | −0.122 (−0.219, −0.025) | 0.014 | ||
| ȃPeroperative | 0.001 (−0.005, 0.008) | 0.655 | ||
| Setting | ||||
| ȃUpfront | −0.002 (−0.009, 0.004) | 0.454 | ||
| ȃAfter neoadjuvant therapy | 0.021 (−0.020, 0.063) | 0.312 | ||
| Subgroup | 0.2957 (0.1440, 0.4473)† | <0.001 | ||
| ȃStandard SLNB | −0.0001 (−0.007, 0.006) | 0.890 | ||
| ȃDelayed SLNB | −0.350 (−0.498, −0.202) | <0.001 | ||
| Injection volume (ml) | ||||
| ȃ0.5 | −0.035 (−0.080, 0.011) | 0.132 | ||
| ȃ1.0 | −0.016 (−0.067, 0.034) | 0.524 | ||
| ȃ1.5 | 0.011 (−0.022, 0.044) | 0.516 | ||
| ȃ2.0 | −0.011 (−0.024, 0.003) | 0.121 | ||
| ȃ5.0 | −0.001 (−0.007, 0.010) | 0.518 | ||
Values in parentheses are 95% confidence intervals. Coefficient for *preoperative injection or †standard sentinel lymph node dissection. SPIO, superparamagnetic iron oxide nanoparticles; SLNB, sentinel lymph node biopsy.