Table 3.

Diagnostic statistics for independent markers.

Variable	AUC	Cutoff value	p value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Age (year)	0.670 (0.588, 0.745)	53	0.006	58.06	72.03	35.3	86.7
AST (U/L)	0.729 (0.650, 0.798)	86.5	<0.001	48.39	89.83	55.6	86.9
ALP (U/L)	0.599 (0.516, 0.678)	196.3	0.112	45.16	79.66	36.8	84.7
TG (mmol/L)	0.541 (0.458, 0.623)	4.69	0.447	96.77	22.03	24.6	96.3
CREA (μmol/L)	0.779 (0.704, 0.843)	79.4	<0.001	77.42	70.34	40.7	92.2
CRP (mg/L)	0.511 (0.404, 0.618)	18.1	0.961	30	90	42.9	83.7
PCT (ng/mL)	0.680 (0.594, 0.758)	3.44	0.002	64.52	71.84	40.8	87.1
APACHE	0.747 (0.669, 0.814)	14	<0.001	93.55	44.07	30.5	96.3
Imire	0.727 (0.684, 0.796)	3	<0.001	74.19	64.41	35.4	90.5
Marshall	0.743 (0.665, 0.811)	1	<0.001	74.19	72.03	41.1	91.4
Clinical model	0.875 (0.811, 0.924)	0.237	<0.001	77.42	83.05	54.5	93.3

ALP: alkaline phosphatase; AST: aspartate aminotransferase; CREA: creatinine; CRP: C-reactive protein; TG: triglycerides; NPV: negative predictive value; PCT: Procalcitonin; PPV: positive predictive value; Youden’s Index: sensitivity + specificity-1.