Table 1:

Comparison of Cryoprecipitate and No-Cryoprecipitate Groups

	No Cryoprecipitate (n=297)	Cryoprecipitate (n=152)	p value
Demographics
Age (years) (n=449)	8 (2–15)	5 (0.5–14)	0.007
Sex (n=449)
Male	172 (58)	75 (49)
Female	125 (42)	77 (51)	0.09
Race (n=380)
White	146 (60)	96 (71)
Black	88 (36)	21 (16)
Other	11 (4)	18 (13)	<0.001
Ethnicity: Hispanic/Latino (n=392)	26 (10)	17 (13)	0.50
Body Mass Index (n=321)	19 (16–23)	17 (14–23)	0.003
Blood Group (n=453)
A	98 (34)	59 (39)
B	40 (14)	25 (16)
AB	8 (3)	4 (3)	0.54
O	139 (49)	63 (42)
Indication for transfusion (n=449)
Trauma	158 (53)	49 (32)
Operative	82 (28)	71 (47)	<0.001
Medical	57 (19)	32 (21)
Pre- life threatening hemorrhage (LTH) variables
PRISM score* (n=428)	12 (5–21)	15 (8–24)	0.004
Lowest Glasgow Coma Scale score (n=280)	8 (3–15)	6 (3–14)	0.31
Lowest temperature (n=339)	36.2 (35.4–36.6)	36.1 (35.1–36.6)	0.54
Age-adjusted hypotension (n=443)	163 (55)	92 (62)	0.22
Age-adjusted tachycardia (n=422)	164 (59)	99 (68)	0.08
Hematocrit (n=420)	29.4 (23.4–35.5)	28.9 (24–34.5)	0.9
International Normalized Ratio (INR) (n=398)	1.4 (1.2–1.7)	1.4 (1.2–2.0)	0.16
Platelet count (n=333)	180 (85–265)	121 (59–217)	0.003
Base deficit/excess (n=389)	0 (−5–6)	0 (−5–5)	0.66
Fibrinogen before LTH	182 (142–246) (n=183)	212 (114–293) (n=112)	0.45
Fibrinogen after LTH	194 (157–251) (n=154)	234 (189–309) (n=93)	0.003

^*The PRISM III score includes: systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, Pa02/Fi02, PaC02, Glasgow Coma Scale score, pupillary reaction, prothrombin time, partial thromboplastin time, total bilirubin, potassium, calcium, glucose, and bicarbonate.

⁺numeric values are median(IQR) when continuous and n (%) when discrete