Table 2.

Blood product administration and unadjusted mortality compared between cryoprecipitate group and no cryoprecipitate group.

	No Cryoprecipitate (n=297)	Cryoprecipitate (n=152)	p value
Blood products and adjuncts
Duration of massive transfusion event (n=449)	2.7 (1.0–5.0)	4.8 (3.0–7.7)	<0.001
Total volume mL/kg (n=449)	41 (20–77)	120 (67–236)	<0.001
Red blood cell volume mL/kg (n=449)	24 (12–46)	56 (28–121)	<0.001
Plasma volume mL/kg (n=449)	12 (0–24)	32 (16–67)	<0.001
Platelet volume mL/kg (n=449)	3 (0–11)	21 (10–42)	<0.001
Cryoprecipitate volume mL/kg (n=449)	-	4 (2–9)	-
Plasma deficit (n=449)	10 (0–24)	19 (2–59)	<0.001
Platelet deficit (n=449)	18 (8–35)	31 (10–83)	<0.001
Plasma:Red blood cell ratio (n=449)	0.5 (0–0.85)	0.6 (0.36–0.91)	0.002
Platelet:Red blood cell ratio (n=423)	0.13 (0–0.32)	0.31 (0.18–0.56)	<0.001
Antifibrinolytics (yes/no) (n=449)	31 (10)	25 (16)	0.07
Factor VII (yes/no) (n=447)	17 (6)	39 (26)	<0.001
Crystalloid volume mL/kg (n=445)	18 (1–50)	14 (1–57)	0.58
Outcome
Mortality – 6 hours (n=69)	54/297 (18)	15/152 (10)	0.03
Death due to bleeding	41/69 (76)	13/15 (87)	0.49
Death during LTH	13/54 (24)	7/15 (46)	0.11
Mortality – 24 hours (n=99)	71/297 (24)	28/152 (18)	0.23
Mortality – 28 days (n=168)	104/297 (35)	64/152 (43)	0.12
Acute Respiratory Distress Syndrome	52 (17)	29 (26)	0.05
Sepsis	31 (10)	13 (9)	0.62
Acute Kidney Injury	38 (13)	45 (30)	<0.001

^*The PRISM III score includes: systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, Pa02/Fi02, PaC02, Glasgow Coma Scale score, pupillary reaction, prothrombin time, partial thromboplastin time, total bilirubin, potassium, calcium, glucose, and bicarbonate.

⁺numeric values are median(IQR) when continuous and n (%) when discrete