. 2023 Jul 10;10:1214016. doi: 10.3389/fnut.2023.1214016

Table 5.

Study outcomes for each subgroup at genus level for all studies and all sampling times (pre-intervention, during-intervention, post-intervention) for molecular-based analyses.

Phylum	Genus	Space									Simulation									Natural, earth-bound
Phylum	Genus	In-mission			Post-mission			Pre/post			In-mission			Post-mission			Pre/post			In-mission		Post-mission		Pre/post
Verrucomicrobiota	Akkermansia (spp.)		↓³						R³						↓⁵
Bacteroidota	Alistipes (spp.)	↑²				↓²		↑²		↔²	↑⁶	↓¹¹				↔⁶		pR⁶			↓¹³
Bacillota	Anaerostipes (spp.)											↓^4,10
Bacteroidota	Bacteroides (spp.)	↑²	↓²		↑²	↓²		↑²	↓²		↑^4,5	↓^6,10,11	↔⁶	↑⁶	↓⁶	↔⁶		pR⁶			↓^12,13	↑¹²			R¹²
Actinomycetota	Bifidobacterium (spp.)		↓²	↔²	↑²		↔²					↓¹⁰								↑^12,13	↓¹²	↑¹²			R¹²
Bacillota	Blautia (spp.)	↑²		↔²	↑²	↓²		↑²		↔²	↑⁷	↓⁴			↓⁷
Bacteroidota	Butyricimonas											↓¹¹
Bacillota	Christensenellaceae										↑⁴
Bacillota	Clostridium (spp.)	↑²		↔²		↓²			↓²			↓¹⁰								↑¹²	↓^12,13	↑¹²	↓¹²
Bacillota	Coprococcus (spp.)								↓³				↔^5,6					pR⁶
Bacillota	Dialister											↓¹¹	↔⁶		↓⁶	↔⁶		pR⁶
Bacillota	Dorea (spp.)		↓³						R³				↔⁵
Pseudomonadota	Enterobacter (spp.)											↓¹⁰
Bacillota	Enterobacteriales																				↓¹²		↓¹²
Pseudomonadota	Escherichia (spp.)		↓²		↑²	↓²			↓²	↔²		↓¹⁰
Bacillota	Eubacterium (spp.)	↑²	↓^2,3			↓²		↑²	↔²	R³
Bacillota	Faecalibacterium (spp.)	↑³	↓²	↔²		↓²			↓²	R³	↑^7,11	↓^4,5,10			↓⁷			pR⁶
Bacillota	Flavonifractor																				↓¹³
Bacillota	Fusicatenibacter	↑³							R³
Bacillota	Kineothrix										↑⁴
Pseudomonadota	Klebsiella																				↓¹³
Bacillota	Lachnospira	↑³							R³		↑⁷	↓^4,11			↓⁷
Bacillota	Lachnospiraceae	↑³							R³		↑_4,10
Bacillota	Lactobacillus (spp.)	↑²	↓²			↓²	↔²		↓²			↓⁴								↑¹³
Bacillota	Lactococcus																				↓¹³
Fusobacteria	Leptotrichia		↓³						R³
Bacillota	Megamonas										↑⁶			↑⁶				pR⁶
Bacillota	Megasphaera		↓³						R³
Bacteroidota	Parabacteroides											↓¹¹
Pseudomonadota	Parasutterella	↑³							R³
Bacillota	Phascolarctobacterium											↓⁶	↔⁶	↑⁶	↓⁶	↔⁶		pR⁶
Bacteroidota	Prevotella (spp.)	↑²	↓³			↓²		R³	↓²	↔²	↑^10,11	↓^6,7	↔⁶	↑^6,7	↓⁶		↑⁶	↓⁶	R		↓¹³
Bacillota	Pseudobutyrivibrio		↓³						R³		↑¹¹
Bacillota	Roseburia (spp.)	↑²				↓²			↓²			↓⁴									↓¹³
Bacillota	Ruminiclostridium	↑³							R³
Bacillota	Ruminococcaceae										↑⁴
Bacillota	Ruminococcus (spp.)		↓³						↓³		↑⁴	↓^4,11
Bacillota	Streptococcus		↓³						R³		↑⁴									↑¹³	↓¹³
Bacillota	Subdoligranulum										↑¹¹
Bacillota	Veillonella		↓³						R³		↓¹⁰

Microbiota abundance fluctuations/continuities identified at genus level in (1) Subgroup 1: Isolation in Space [Study ID 1–3, molecular-based approaches (Tables 2, 4)], (2) Subgroup 2: Isolation in a simulation unit [Study ID 4–11, molecular-based approaches (Tables 2, 4)], and (3) Subgroup 3: Natural earth-bound isolation [Study ID 12–13, molecular-based approaches, (Tables 2, 4)] either (i) through the intervention compared to baseline (in-mission) or (ii) after the isolation period compared to the intervention (post-mission) or (iii) after the isolation compared to baseline (pre−/post-mission).

↓, Relative abundance decreased; ↑, Relative abundance increased; ↔, No significant shifts in relative abundance. R, Restored back to baseline level. pR, partially restored back to baseline. Studies have reported only on genus level or also including some species (spp.).