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. 2023 Jul 20;15(1):2236755. doi: 10.1080/19490976.2023.2236755

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — Old donor mice have lower lean mass and bone mass compared with young adult donor mice.

21-month-old mice (old) and 5-month-old mice (young adult) were analyzed by dual-energy x-ray absorptiometry (DXA) to determine lean% (a). The tibia was dissected from each animal and analyzed by high-resolution microCT (µCT) to determine the trabecular BV/TV (b) and cortical thickness (c). Bone marrow cells were harvested from the femur and stained for CD4, Foxp3, and CD25 to analyze CD4+ cells (d) and regulatory T cells (Treg, CD4+CD25+Foxp3+, E). Values are given as mean ± SEM. Data were statistically analyzed using Student’s t-test. ***p ≤ 0.001.