Table 1.
Demographics of test and validation gastric cancer cohorts
| Test cohort (n = 206) | Validation cohort (n = 748) | |||||||
|---|---|---|---|---|---|---|---|---|
| CS | CINlow | CINhigh | P* | CS | CINlow | CINhigh | P* | |
| Age (years) | ||||||||
| < 65 | 58 (28) | 34 (17) | 9 (4) | 0.027 | 66 (9) | 74 (10) | 41 (6) | 0.056 |
| ≥ 65 | 45 (22) | 38 (18) | 22 (11) | 163 (22) | 287 (38) | 114 (15) | ||
| Sex | ||||||||
| Males | 66 (32) | 46 (22) | 16 (8) | 0.424 | 105 (21) | 161 (32) | 59 (12) | 0.260 |
| Females | 37 (18) | 26 (13) | 15 (7) | 63 (13) | 72 (15) | 37 (7) | ||
| Treatment | ||||||||
| Surgery only | 37 (18) | 37 (18) | 15 (7) | 0.104 | 167 (22) | 231 (31) | 94 (13) | 0.758 |
| Surgery and chemotherapy | 66 (32) | 35 (17) | 16 (8) | 1 (0) | 2 (0) | 2 (0) | ||
| Chemotherapy only | – | – | – | 24 (3) | 45 (6) | 26 (4) | ||
| Supportive care only | – | – | – | 38 (5) | 85 (11) | 33 (4) | ||
| TNM stage | ||||||||
| I | – | – | – | 0.585 | 14 (2) | 28 (4) | 9 (1) | 0.144 |
| II | 37 (18) | 33 (16) | 12 (6) | 45 (6) | 56 (8) | 30 (4) | ||
| II | 63 (31) | 38 (18) | 19 (9) | 82 (11) | 106 (14) | 39 (5) | ||
| IV | 3 (2) | 1 (1) | 0 (0) | 89 (12) | 173 (23) | 77 (10) | ||
| Histological phenotype | ||||||||
| Intestinal | 29 (14) | 22 (11) | 16 (8) | 0.185 | 88 (18) | 142 (29) | 72 (15) | 0.006 |
| Diffuse | 68 (33) | 46 (22) | 14 (7) | 55 (11) | 58 (12) | 13 (2) | ||
| Mucinous/mixed | 6 (3) | 4 (2) | 1 (0) | 24 (5) | 31 (6) | 11 (2) | ||
| p53 immunohistochemistry | ||||||||
| High expression | 68 (33) | 51 (25) | 12 (6) | 0.005 | 104 (22) | 108 (23) | 37 (8) | <0.001 |
| Low expression | 35 (17) | 20 (10) | 19 (9) | 55 (12) | 111 (23) | 56 (12) | ||
Values in parentheses are percentages. *Fisher's Exact test.