Table 1.
Characteristics used for inverse probability of treatment weighting
| Patient characteristics | Disease characteristics | Treatment characteristics |
|---|---|---|
| Sex | Tumour site | Completion of preoperative chemotherapy |
| Age | ypT category | Time from diagnosis to surgery |
| ASA fitness grade | ypN category | Surgical approach |
| Performance status | CRM involvement | Hospital volume |
| Ischaemic heart disease | Differentiation grade | Complications (any) |
| COPD/asthma | Anastomotic leak | |
| Chronic kidney disease | Respiratory complications | |
| Diabetes mellitus | Duration of hospital stay | |
| Total no. of co-morbidities | Surgical procedure | |
| Social deprivation* | Preoperative chemotherapy regimen (platinum-based triplet or FLOT) |
*English Index of Multiple Deprivation. CRM, circumferential resection margin, defined according to the Royal College of Pathologists guidelines (positive if tumour found at or within 1 mm of cut edge)30; COPD, chronic obstructive pulmonary disease; FLOT, fluorouracil, leucovorin, oxaliplatin, docetaxel.