Table 1.
Clinical demographics and perioperative details of patients undergoing distal pancreatectomy
| Development cohort, Helsinki (n = 266) | Validation cohort, Stockholm (n = 402) | P† | |
|---|---|---|---|
| Age (years), median (i.q.r.; range) | 64 (54–71; 18–89) | 67 (56–73; 20–89) | 0.073‡ |
| BMI (kg/m2), median (i.q.r.; range) | 26.23 (23.84–29.84; 17.21–44.62) | 25.77 (22.70–29.33; 14.90–40.0) | 0.068‡ |
| Charlson Co-morbidity Index score, median (i.q.r.; range) | 2 (1–4; 0–13) | 1 (0–2; 0–10) | <0.001‡ |
| PT at pancreatic neck (mm), median (i.q.r.; range) | 12 (10–15; 5–23) | 14 (12–17; 5–29) | <0.001‡ |
| PT at transection site (mm), median (i.q.r.; range) | 16 (13–20; 5–35) | 15 (13–19; 5–32) | 0.18‡ |
| MPDD at pancreatic neck (mm), median (i.q.r.; range) | 2.5 (1.5–3; 1–13) | 2 (2–3, 1–13) | 0.006‡ |
| MPDD at transection site (mm), median (i.q.r.; range) | 2 (1.5–3; 1–8) | 2 (2–3; 1–13) | 0.96‡ |
| Estimated blood loss (ml), median (i.q.r.; range) | 300 (100–800; 0–8800) | 200 (100–500; 0–16 500) | <0.001‡ |
| Duration of initial hospital stay (days), median (i.q.r.; range) | 7 (5–9; 3–39) | 7 (9–14; 3–133) | <0.001‡ |
| Men | 107 (40.2) | 183 (45.5) | 0.20 |
| Diabetes mellitus | 55 (20.7) | 77 (19.2) | 0.62 |
| Ever smoked | 92 (34.6) | n.a. | |
| Neoadjuvant therapy | 32 (12.0) | 12 (3.0) | <0.001 |
| Benign pathology | 91 (36.0) | 185 (46.0) | 0.012 |
| Administration of somatostatin analogue* | 147 (55.3) | 108 (26.9) | <0.001 |
| Transection using stapler | 226 (85.0) | 202 (50.2) | <0.001 |
| Serrated pancreatic parenchyma | 122 (45.9) | 226 (56.2) | 0.015 |
| Transection at pancreatic neck | 159 (59.8) | 352 (87.6) | <0.001 |
| CR-POPF | 52 (19.5) | 121 (30.1) | 0.003 |
Values are n (%) unless otherwise indicated.
*
Pasireotide used prophylactically at Helsinki University Hospital; octreotide used as a treatment for clinically relevant postoperative pancreatic fistula (CR-POPF) (grade B or C) at Karolinska University Hospital. PT, pancreatic thickness; MPDD, main pancreatic duct diameter; n.a., data not available. †Fisher’s exact test, except ‡Mann-Whitney U test.