Fig. 4.

Overall survival, cause-specific survival and time to recurrence

Intention-to-treat (ITT) analysis of a overall survival (hazard ratio (HR) 1.07, 95 per cent c.i. 0.80 to 1.43; P = 0.633), b cause-specific survival (HR 0.86, 0.54 to 1.44; P = 0.609), and c time to recurrence (HR 0.86, 0.51 to 1.43; P = 0.558); per-protocol (PP) analysis of d overall survival (HR 0.81, 0.49 to 1.33; P = 0.404), e cause-specific survival (HR 0.56, 0.24 to 1.29; P = 0.171), and f time to recurrence (HR 0.48, 0.17 to 1.31; P = 0.150).