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. Author manuscript; available in PMC: 2023 Jul 24.
Published in final edited form as: Curr Opin Microbiol. 2022 Oct 12;70:102208. doi: 10.1016/j.mib.2022.102208

Table 1.

Characterized mechanisms of triazole resistance and their associated impact on fluconazole MIC.

Triazole-resistance mechanism Amino acid substitutions Impact on fluconazole MIC if known
ERG11 mutations – –
 Predominant VF125AL, Y132F, K143R 8–16-fold increase
 Less-commonly reported L43H, Q357K, F444L, G459S, I466M, Y501H Fourfold increase
TAC1B mutations – –
 Predominant A640V, A657V, F862_N866del 16-fold increase
 Less-commonly reported A15T, S192N, S195C, F214S, K247E, R495G, A583S, P595L/H, S611P, A651T, M653V Fourfold increase
MRR1A mutations – –
 Predominant N647T Fourfold increase

Mutations in bold have been characterized and impact on fluconazole MIC is shown in the adjacent column.