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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2022 Sep 29;29(10):966–977. doi: 10.1038/s41594-022-00841-4

Fig. 2 |. The 2.17-Å structure of the SMP complex.

Fig. 2 |

a,b, The overall structure of the SMP complex is shown as a cartoon (a) and in surface representation (b) in two different views. SHOC2 and PP1CA are colored pink and green, respectively. MRAS is colored blue, with the switch I and switch II regions highlighted in dark blue and purple, respectively. GMPPNP is shown as sticks, and Mg2+ (green) and Mn2+ (gray) ions as spheres. The active site containing Mn2+ ions is within the black circle. c, Superposition of the two SMP complexes present in the asymmetric subunit in cartoon form. Both chains of MRAS and PP1CA are in the same color, and the two SHOC2 chains are colored pink and cyan. d, Superposition of apo-SHOC2 (yellow) onto the two SHOC2 chains from the SMP complex.