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. 2022 May 23;2:895088. doi: 10.3389/fradi.2022.895088

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Copyright © 2022 Yi, Pirasteh, Wang, Bradshaw, Jeffery, Barnett, Stowe, McMillan, Vivas, Rey and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Fused axial PET/CT images of male P90 HG (top row) and GF (bottom row) mice following the injection of ¹⁸F-SynVesT-1 demonstrating the qualitative higher uptake of the SynVesT-1 radiotracer in GF mice. (B) Static ¹⁸F-FDG images of HG (top row) and GF (bottom row). (C) Time-activity curves (mean ± SD) of male GF and HG P90 mice. The area under the curve was calculated for the peak stabilized interval (4.5–10.5 min) for ¹⁸F-SynVesT-1 (D) and ¹⁸F-FDG (E). HG, humanized gnotobiotic mice; GF, germ-free; *p< 0.05.