Table 2.
Gut microbiota are associated with significant alterations in synaptic density.
| 18F-SynVesT-1 | ROI | Mean (±SEM) | p-value | |
|---|---|---|---|---|
| Germ-free | Humanized gnotobiotic | |||
| SUV (mean) | HC | 0.97565 (±0.04420) | 0.76368 (±0.04091) | <0.05 |
| NC | 0.82295 (±0.03747) | 0.67343 (±0.03653) | <0.05 | |
| AM | 0.90888 (±0.02732) | 0.73379 (±0.04848) | <0.05 | |
| VT | 1.04453 (±0.06381) | 0.79085 (±0.03936) | <0.05 | |
| LT | 1.08326 (±0.06756) | 0.80882 (±0.04963) | <0.05 | |
| GP | 1.03449 (±0.06282) | 0.80712 (±0.04187) | <0.05 | |
| CP | 1.01670 (±0.07021) | 0.79078 (±0.04224) | 0.051 | |
| HT | 0.98326 (±0.05794) | 0.76001 (±0.03679) | <0.05 | |
| AC | 1.08539 (±0.07685) | 0.81797 (±0.04625) | <0.05 | |
| SUVR (cerebellum) | HC | 1.44382 (±0.06410) | 1.24986 (±0.02023) | <0.05 |
| NC | 1.21725 (±0.04783) | 1.10206 (±0.01726) | 0.086 | |
| AM | 1.34478 (±0.03501) | 1.19967 (±0.03569) | <0.05 | |
| VT | 1.54504 (±0.08755) | 1.29514 (±0.02959) | 0.054 | |
| LT | 1.60232 (±0.09286) | 1.32233 (±0.01354) | <0.05 | |
| GP | 1.53034 (±0.08726) | 1.32165 (±0.03408) | 0.090 | |
| CP | 1.50353 (±0.09553) | 1.29435 (±0.02525) | 0.102 | |
| HT | 1.45480 (±0.08210) | 1.24527 (±0.03796) | 0.081 | |
| AC | 1.60566 (±0.10849) | 1.33834 (±0.02545) | 0.074 | |
All values are mean ± standard error of the mean. Unit of measure is g/mL. Bolded and italicized p values are statistically significant. HC, hippocampus; NC, neocortex; AM, amygdala; VT, ventral thalamus; LT, lateral thalamus; GP, globus pallidus; CP, caudate putamen; HT, hypothalamus; AC, accumbens. HC, NC, and A were examined a priori, whereas the other ROIs were chosen for exploratory analysis.