TABLE 4.
Least square mean (95% confidence interval) for sodium, chloride, ionized magnesium, potassium, creatinine, and blood urea nitrogen concentrations for the CONT, IV, and RECT treatments at different time points in 5 pigs enrolled in a cross‐over design.
| Analyte | Treatment | T0 | T6 | T12 |
|---|---|---|---|---|
| Sodium (mmol/L) | CONT | 143 (141, 145) | 142 (140, 144) | 144 (142, 144) |
| IV | 146 (144, 148) | 146 (143, 148) | 145 (143, 148) | |
| RECT | 141 (139, 143) | 141 (139, 143) | 140 (138, 142) | |
| Chloride (mmol/L) | CONT | 102 (99, 104) | 102 (99, 104) | 101 (99, 104) |
| IV | 104 (102, 107) | 104 (102, 107) | 104 (101, 106) | |
| RECT | 100 (98, 103) | 100 (99, 103) | 100 (98, 103) | |
| Ionized magnesium (mmol/L) | CONT | 0.42 (0.39, 0.44) | 0.43 (0.40, 0.45) | 0.41 (0.39, 0.44) |
| IV | 0.42 (0.39, 0.44) | 0.41 (0.39, 0.44) | 0.42 (0.40, 0.45) | |
| RECT | 0.41 (0.39, 0.44) | 0.43 (0.41, 0.46) | 0.43 (0.41, 045) | |
| Potassium (mmol/L) | CONT | 4.1 (3.9, 4.3) | 4.1 (4.0, 4.4) | 4.2 (3.9, 4.4) |
| IV | 4.1 (3.9, 4.3) | 4.0 (3.7, 4.1) | 4.0 (3.8, 4.2) | |
| RECT | 4.1 (3.9, 4.4) | 4.1 (3.9, 4.4) | 4.4 (4.2, 4.6) | |
| Albumin (g/dL) | CONT | 3.9 (3.8, 4.1) | 4.0 (3.8, 4.1) | 4.1 (3.9, 4.2) |
| IV | 4.2 (4.0, 4.4)a | 3.9 (3.7, 4.1)b | 4.0 (3.9, 4.2)a, b | |
| RECT | 3.7 (3.5, 3.8) | 3.7 (3.5, 3.8) | 3.7 (3.5, 3.8) | |
| Creatinine (mg/dL) | CONT | 0.9 (0.8, 1.0) | 0.9 (0.7, 1.0) | 0.9 (0.8, 1.0) |
| IV | 0.9 (0.8, 1.0) | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) | |
| RECT | 0.8 (0.7, 1.0) | 0.8 (0.6, 0.9) | 0.8 (0.7, 0.9) | |
| Blood urea nitrogen (mg/dL) | CONT | 7.2 (5.2, 9.2) | 7.8 (5.8, 9.8) | 9.4 (7.4, 11.4) |
| IV | 11.2 (9.2, 13.2)c | 6.8 (4.8, 8.8)d | 5.0 (3.0, 7.0)d | |
| RECT | 8.0 (6.0, 10.0) | 8.4 (6.4, 10.4) | 8.4 (6.4, 10.4) |
Note: Albumin and blood urea nitrogen concentrations for the IV treatment—comparisons (treatment and time interactions) with different superscripts are significantly different (P < .05) for the analyte. All other interaction comparisons between treatment and time were not significant (P > .05). CONT—control treatment. IV—IV treatment. RECT—per rectum infusion treatment. T0—time before treatment. T6 and T12 represent 6 and 12 hours after the beginning of the treatments at sample collection.