Skip to main content
. 2023 Jun 28;37(4):1488–1492. doi: 10.1111/jvim.16750

FIGURE 3.

FIGURE 3

Hemangiosarcoma in the urinary bladder of a domestic shorthair cat. (A) All layers of the urinary bladder, urothelium (arrows), lamina propria, and the detrusor muscle (arrowhead) are extensively effaced multifocally and expanded by a poorly demarcated, infiltrative, malignant mesenchymal neoplasm. Neoplastic cells either form dense, confluent solid streams and whorls of plump spindloid cells (circle) or irregular vascular spaces and channels (asterisk). Hematoxylin‐eosin (HE). Bar, 1 cm. (B) Neoplastic endothelial cells have moderate anisocytosis and anisokaryosis with occasional mitoses (arrow). HE. Bar, 50 μm. (C) Neoplastic cells show positive immunolabeling of von Willebrand factor (vWF) antigen. Immunohistochemistry (IHC). Bar, 50 μm. Inset: A higher magnification view of the neoplastic endothelial cells expressing vWF antigen. IHC. Bar, 20 μm.