. 2023 May 19;37(4):1390–1400. doi: 10.1111/jvim.16727

TABLE 1.

Summary of ADP‐mediated whole blood platelet aggregometry in 9 cats receiving 7 days of rivaroxaban, clopidogrel or dual agent therapy.

Inhibition (%)

Rivaroxaban

AUC = 80 (72.5‐144.5)

Vel = 31.8 (16.2‐36.9)

Ag_max = 150.4 (108.6‐233.4)

AUC = 118 (112.5‐130.5)

Vel = 42.0 (33.9‐44.2)

Ag_max = 186.4 (176.5‐208.0)

AUC = −49.4% (−68.8‐6.1)

Vel = −42.1% (−144.8‐9.6)

Ag_max = −18.4% (−73.6‐3.6)

Clopidogrel

AUC = 135 (107.5‐145.0)

Vel = 38.2 (36.3‐42.4)

Ag_max = 211.9 (168.7‐232.2)

AUC = 0 (0‐22.5) ^a

Vel = 0 (0‐5.1) ^a

Ag_max = 0 (0‐43.1) ^a

AUC = 100% (84.3‐100) ^b

Vel = 100% (87.3‐100) ^b

Ag_max = 100% (81.6‐100) ^b

DAT

AUC = 73 (50.5‐125.5)

Vel = 23.5 (14.8‐30.9)

Ag_max = 117.9 (74.0‐207.8)

AUC = 9 (0‐18.5) ^a

Vel = 2.9 (0‐7.4) ^a

Ag_max = 20.4 (0‐60.8) ^a

AUC = 90.84% (73.6‐100) ^c

Vel = 87.7% (69.3‐100) ^c

Ag_max = 85.0% (42.3‐100) ^c

Note: All data are presented as median (interquartile range).

Abbreviations: Agmax, maximum aggregation; AUC, area under the curve; DAT, dual agent therapy; Vel, velocity (arbitrary unit/min).

^{^a}

P < .05; D0 vs D7.

^{^b}

P < .05; Rivaroxaban vs Clopidogrel.

^{^c}

P < .05; Rivaroxabvan vs DAT.