TABLE 2.
Correlation between plasma rivaroxaban concentrations and changes in platelet dependent thrombin generation.
| Change (%) in thrombin generation | ||||
|---|---|---|---|---|
| AUC | T max | Peak Thrombin | V max | |
| −45.8 (IQR: −74.2 to 28.5) | 346 (IQR: 41.4 to 1006) | −10.8 (IQR: −40.8 to −3.3) | −51.7 (IQR: −78.8 to 25.6) | |
| RIVA Anti‐Xa | R = 0.39 | R = 0.18 | R = −0.65 | R = −0.78 |
| P‐value | .39 | .64 | .067 | .0017 |
| −61.3 (IQR: −70.0 to −10.9) | 133 (IQR: 111.4 to 239.4) | −78.2 (IQR: −87.6 to −70.0) | −75.3 (IQR: −85.9 to 53.7) | |
| DAT Anti‐Xa | R = −0.23 | R = 0.14 | R = −0.84 | R = −0.84 |
| P‐value | .56 | .14 | .0070 | .0070 |
Abbreviations: AUC, area under the curve; RIVA, rivaroxaban; T max, time to maximum thrombin generation; V max, maximum velocity.