FIGURE 1.

Repeated measures and a randomized block design in the present study. All types of acid‐base disorders were experimentally induced. Ten minutes before producing metabolic or respiratory acid‐base disorders, the acid‐base state was controlled normally. Blood samples were collected once in each state. It took 1 to 3 hours to wash out between these acid‐base states. These six states could be randomly arranged in eight blocks. One dog was allocated to each block. Therefore, eight experiments were completely performed.