TABLE 1.
Baseline characteristics of the study populations (n = 38).
| PHA | CKD‐H | CKD‐NH | HTH | ISH | Healthy | Reference interval | |
|---|---|---|---|---|---|---|---|
| n | 5 | 9 | 7 | 9 | 2 | 6 | |
| Age (years) | 10 [10; 17] | 15 [14; 17] | 15 [8; 15] | 16 [14; 17] | 12 [9; 14] | 8 [7; 9] | |
| Urea (mmol/L) | 10.0 [6.5; 15.0] | 15.3 [12.0; 21.2] | 12.5 [12.0; 26.0] | 13.0 [8.0; 14.7] | 11.0 [4.20; 17.9] | 9.5 [5.8; 9.9] | 6.7‐13.4 |
| Creatinine (μmol/L) | 128 [90; 177] | 186 [168; 305] | 168 [151; 186] | 96 [84; 124] | 97 [80; 115] | 89 [80; 97] | 46‐142 |
| Urine specific gravity | 1.030 [1.026; 1.040] | 1.016 [1.015; 1.025] | 1.015 [1.012; 1.018] | 1.028 [1.018; 1.031] | 1.030 [1.025; 1.035] | 1.016 [1.012; 1.020] | >1.035 |
| Aldosterone (pmol/L) | 2 914 [2.789‐4.600] | 239 [189‐577] | 353 [136‐1 371] | 389 [264‐478] | 344 [169‐519] | 137 [128‐227] | 14‐258 |
| Plasma renin activity (pmol/L/h) | 2123 [352; 10 377] | 193 [160; 494] | 2450 [778; 7080] | 634 [575; 3296] | 462 [351; 572] | 578 [253; 906] | Not determined yet |
| T4 (nmol/L) | 25 [6; 56] | 27 [25; 36] | 16 [6; 23] | 108 [77; 176] | 32 [27; 37] | 28 [23; 31] | 15‐50 |
| Sodium (mmol/L) | 149 [145; 154] | 157 [154; 158] | 149 [145; 156] | 152 [152; 153] | 158 [157; 159] | 155 [154; 157] | 150‐165 |
| Potassium (mmol/L) | 2.4 [2.4; 2.8] | 4.1 [3.9; 4.7] | 4.4 [3.5; 4.7] | 4.1 [4.1; 4.6] | 4.0 [3.9; 4] | 4.2 [4.1; 4.6] | 3.6‐5.5 |
| Blood pressure (oscillometry, mmHg) | 220 [210; 220] | 220 [200; 230] | 140 [135; 150] | 160 [140; 190] | 240 [220; 260] | 138 [130; 140] | 110‐160 |
Note: Results are presented as medians [1st quartile; 3rd quartile].
Abbreviations: CKD‐H and CKD‐NH, hypertensive and non‐hypertensive chronic kidney disease; HTH, hyperthyroidism; ISH, idiopathic systemic arterial hypertension; PHA, primary hyperaldosteronism.