TABLE 1.
Demographic and physical and echocardiographic findings of the per protocol population as measured by the ECL.
| Control | Test | P | |
|---|---|---|---|
| N | 55 | 46 | |
| Age (y) | 10.5 (8.6‐11.1) | 9.9 (8.1‐11) | .1 |
| Sex (male/female) | 35/20 | 30/16 | .87 |
| Body weight (kg) | 8.2 (7.0‐9.7) | 7.9 (5.8‐10.6) | .8 |
| Breed (CKCS/non‐CKCS) | 17/38 | 12/24 | .66 |
| Murmur grade (2/3/4/5/6) | 29/18/6/1/1 | 23/16/6/1 | .82 |
| Systolic blood pressure (mm Hg) | 143 (17) | 144 (17) | .97 |
| Normalized values a | |||
| AoD | 0.71 (0.66‐0.76) | 0.72 (0.68‐0.76) | .51 |
| LAD | 1.00 (0.13) | 1.00 (0.09) | .83 |
| LVIDd | 1.50 (0.16) | 1.47 (0.12) | .38 |
| LVIDs | 0.84 (0.14) | 0.84 (0.12) | .96 |
| IVSd | 0.45 (0.42‐0.48) | 0.45 (0.41‐0.51) | .96 |
| LVPWd | 0.45 (0.05) | 0.45 (0.06) | .77 |
| Absolute values | |||
| LAD (cm) | 2.06 (0.33) | 2.02 (0.29) | .51 |
| AoD (cm) | 1.46 (0.20) | 1.46 (0.20) | .87 |
| LVIDd (cm) | 2.77 (0.37) | 2.71 (0.37) | .42 |
| LVIDs (cm) | 1.63 (0.33) | 1.62 (0.33) | .94 |
| LA : Ao | 1.42 (0.14) | 1.39 (0.14) | .3 |
| FS (%) | 40.0 (36.1‐43.7) | 40.0 (35.2‐44.1) | .64 |
| Emax (m/s) | 0.67 (0.57‐0.73) | .67 (0.59‐0.79) | .44 |
| E : A | 0.98 (0.83‐1.21) | 1.1 (0.83‐1.23) | .32 |
Note: Data are displayed as mean (SD), median (IQR), or count.
Abbreviations: AoD, aortic root diameter; CKCS, Cavalier King Charles Spaniel; E : A, E wave to A wave velocity ratio; ECL, echocardiographic core laboratory; Emax, maximum E wave velocity; FS, fractional shortening; IQR, interquartile range; IVSd, interventricular septum wall thickness at end‐diastole; LA : Ao, left atrial to aortic root diameter ratio; LAD, left atrial diameter; LVIDd, left ventricular internal diameter at end‐diastole; LVIDs, left ventricular internal diameter at end‐systole; LVPWd, left ventricular posterior wall thickness at end‐diastole.
Normalized values derived from Cornell, Kittleson, Della Torre, et al. Allometric scaling of M‐mode cardiac measurements in normal adult dogs. J Vet Intern Med. 2004;18:311‐321.