TABLE 3.
Univariable Cox regression analysis of potential risk factors for the progression‐free interval and overall survival time in 52 small‐breed dogs with surgically resected pulmonary adenocarcinomas.
| Variable | N | Progression‐free interval | Overall survival time | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P‐value | Hazard ratio (95% CI) | P‐value | ||
| Age | 52 | 1.07 (0.88‐1.31) | .48 | 1.27 (1.07‐1.50) | .01 |
| Body weight | 52 | 0.97 (0.83‐1.13) | .69 | 0.92 (0.80‐1.06) | .26 |
| Clinical signs | |||||
| No | 19 | Reference | Reference | ||
| Yes | 33 | 2.67 (1.05‐6.81) | .03 | 2.13 (1.05‐4.29) | .03 |
| Tumor size classification | 52 | <.001 | .04 | ||
| ≤3 cm | 15 | Reference | Reference | ||
| >3 cm to ≤5 cm | 18 | 8.87 (1.12‐70.09) | .04 | 1.62 (0.68‐3.81) | .27 |
| >5 cm to ≤7 cm | 14 | 17.49 (2.19‐139.80) | .007 | 2.13 (0.87‐5.23) | .10 |
| >7 cm | 5 | 43.12 (4.47‐416.20) | .001 | 4.76 (1.51‐15.06) | .01 |
| Lymph node status | |||||
| N0 | 43 | Reference | Reference | ||
| N1, 2 | 9 | 3.44 (1.33‐8.90) | .02 | 2.2 (1.03‐4.70) | .04 |
| Margin | |||||
| Complete | 45 | Reference | Reference | ||
| Incomplete | 7 | 12.54 (4.37‐36.02) | <.001 | 2.92 (1.25‐6.82) | .01 |
| Histologic grade | 52 | .002 | .20 | ||
| Grade 1 | 35 | Reference | Reference | ||
| Grade 2 | 15 | 3.09 (1.31‐7.27) | .01 | 1.78 (0.90‐3.52) | .10 |
| Grade 3 | 2 | 7.36 (1.57‐34.56) | .01 | 2.40 (0.56‐10.41) | .24 |
| Histologic classification | |||||
| Papillary | 45 | Reference | Reference | ||
| Others | 7 | 0.56 (0.16‐1.92) | .36 | 0.44 (0.18‐1.11) | .08 |
| Adjuvant chemotherapy | |||||
| No | 19 | Reference | Reference | ||
| Yes | 29 | 1.33 (0.58‐3.05) | .50 | 0.78 (0.39‐1.53) | .46 |
Abbreviation: CI, confidence interval.