TABLE 4.
Multivariable Cox regression analysis of potential risk factors for the progression‐free interval and overall survival time in 52 small‐breed dogs with surgically resected pulmonary adenocarcinomas.
| Variable | N | Progression‐free interval | Overall survival time | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P‐value | Hazard ratio (95% CI) | P‐value | ||
| Age | 52 | ‐ | ‐ | 1.28 (1.07‐1.53) | .01 |
| Clinical signs | |||||
| No | 19 | Reference | Reference | ||
| Yes | 33 | 1.42 (0.45‐4.51) | .55 | 1.82 (0.80‐4.14) | .15 |
| Tumor size classification | |||||
| ≤3 cm | 15 | Reference | Reference | ||
| >3 cm to ≤5 cm | 18 | 5.74 (0.69‐47.52) | .11 | 1.67 (0.69‐4.04) | .25 |
| >5 cm to ≤7 cm | 14 | 13.68 (1.66‐112.50) | .01 | 1.51 (0.57‐4.00) | .41 |
| >7 cm | 5 | 6.55 (0.47‐91.08) | .16 | 2.00 (0.47‐8.42) | .35 |
| Lymph node status | |||||
| N0 | 43 | Reference | Reference | ||
| N1, 2 | 9 | 2.40 (0.75‐7.66) | .14 | 2.31 (0.99‐5.41) | .05 |
| Margin | |||||
| Complete | 45 | Reference | Reference | ||
| Incomplete | 7 | 5.85 (1.45–23.51) | .01 | 1.20 (0.40‐3.55) | .75 |
| Histologic grade | |||||
| Grade 1 | 35 | Reference | ‐ | ||
| Grade 2 | 15 | 2.61 (0.94‐7.23) | .07 | ‐ | ‐ |
| Grade 3 | 2 | 1.94 (0.20‐18.99) | .57 | ‐ | ‐ |
Abbreviation: CI, confidence interval.