TABLE 2.

Overview of hereditary ataxias in dogs without known genetic variant (adapted from Urkasemsin et al ¹ ).

Disease name	Breed	Onset	Progression	Cases	References
Cerebellar cortical degenerations
Primary Purkinje cell degeneration	Rhodesian Ridgeback a	2 weeks	Rapid	9 related cases	Chieffo et al 39
	Labrador Retriever	9‐17 weeks 7 weeks 3.5‐6 months	Rapid Slow /	3 littermates 1 case 5 cases	Perille et al 38 Bildfell et al 40 Sen et al 41
	Labrador Retriever	4 years	Slow	1 case	Bertalan et al 42
	English Bulldog	10‐12 weeks	Progressive	3 related cases	Gandini et al 43
	Portugese Podenco	2‐3 weeks	Rapid	2 littermates	van Tongeren et al 44
	Azores Cattle Dog	<16 weeks	Progressive	2 littermates	Varejão et al 45
	Miniature Schnauzer	3 months	Rapid	1 case	Berry and Blas‐Machado 46
	Papillon	5 months	Slow	1 case	Nibe et al 47
	Boxer	3 years and 3 months	Progressive	1 case	Gumber et al 48
	Lagotto Romagnolo	5 weeks	Rapid and then stabilizes	1 case	Jokinen et al 49
	Samoyed	4‐6 weeks	Rapid and then stabilizes	2 cases	de Lahunta et al 4
	Bernese Mountain Dog b	4‐6 weeks	Progressive	7 related cases	Carmichael et al 50
Primary granule cell degenerations	Rough Coated Collie	4‐8 weeks	Rapid	39 related cases autos recessive	Hartley et al 51
	Jack Russel Terrier	2 weeks	Progressive	5 littermates	Coates et al 52
	Border Collie	6‐8 weeks 4 months	Rapid Progressive	2 littermates 2 littermates	Gill and Hewland 53 Sandy et al 54
	Labrador Retriever	13 months	Progressive	3 littermates	Huska et al 55
	Bavarian Mountain Dog	3 months	Slow	3 cases	Flegel et al 56
	Coton de Tulear c	8 weeks	Rapid	3 cases	Tipold et al 57
	Australian Kelpie	6 weeks	Slow	1 case	Huska et al 55
	Italian Hound	3 months	Progressive	1 case	Cantile et al 58
	Lagotto Romagnolo	13 weeks	Rapid	1 case	Jokinen et al 49
	Ibizian Hound	4‐6 weeks	Progressive, may stabilize	3 cases autos recessive	de Lahunta et al 4
Spinocerebellar degenerations
Late onset spinocerebellar degeneration	Brittany Spaniel d	5‐11 years	Slow	8 cases 1 case	Higgins et al 59 de Lahunta et al 4
Central axonopathy	Scottish Terrier	10‐12 weeks	Progressive	3 related cases	van Ham et al 60
Episodic ataxia	Bichon Frise	4 months	Progressive e	1 case	Hopkins and Clarke 61
Other neurodegenerative diseases causing cerebellar dysfunction as core feature
Neuroaxonal dystrophy	Collie sheep dog	2‐4 months	Progressive	6 cases	Clark et al 62
Neuroaxonal dystrophy	Dachsie‐cross	Few weeks	Progressive	2 littermates	Pintus et al 63
Neuroaxonal dystrophy	Boxer	1‐7 months	Progressive	/	Dewey et al 64
Neuroaxonal dystrophy	German Shepherd	15 months	Progressive	/	Dewey et al 64
Neuronal ceroid lipofuscinosis	Dachshund	3 years	Slow progressive	1 case	Cummings and de Lahunta 65
GM2 Gangliosidosis	German Pointer	1 year	Progressive	1 case	Singer et al 66

^a Associated to coat color dilution.

^b Nodular liver, abdominal varicosities, and ascites.

^c Presumed immune‐mediated.

^d Lesions in the medullary general proprioceptive nuclei and spinal cord dorsal horn neurons.

^e Complete resolution of signs was reported following treatment with 4‐aminopyridine.