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The federated GEIDI model on ADNI data. (A) Stratify samples into subgroups with different genotypes of a gene (e.g., APOE) or at a specific SNP locus (e.g., rs942439) (B) Federated GEIDI is used to detect if the relationships between X (imaging biomarker) and Y (gene expression) are different among the subgroups. The p-value of federated GEIDI will then be used to prioritize the trios (genotype-expression-image).
