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. 2022 Jun 14;2:929533. doi: 10.3389/fradi.2022.929533

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Copyright © 2022 Clement, Petr, Dijsselhof, Padrela, Pasternak, Dolui, Jarutyte, Pinter, Hernandez-Garcia, Jahn, Kuijer, Barkhof, Mutsaerts and Keil.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Principle of white matter lesion correction. A T2 FLAIR image (A) with lesion hyperintensities, corresponding to an original T1-weighted image; (B) and a WM segmentation image; (C) from a 70-year-old female. The lesions are automatically identified and segmented on the T2 FLAIR; (D) which are used as a mask to define hypointense regions in T1-weighted images that could be misinterpreted as GM. Based on these lesion masks, the original T1-weighted image is corrected; (E) and shown with the final WM segmentation overlaid in red (F).