Fig. 2.

Design and EKO evaluation of target compounds. (a) The peptide backbone is replaced with two 5-membered aromatic rings. (b) The structure and retrosynthesis of TT-mer. (c) A simulated conformer of TT-mer overlays on the interface triplet found on bovine pancreatic trypsin inhibitor (BPTI) with an RMSD of 0.37 Å.