Table 1.
Demographics and clinical characteristics
| NC (N=19) |
AD (N=12) |
bvFTD (N=56) |
CBS (N=18) |
lvPPA (N=15) |
nfvPPA (N=16) |
PSP (N=13) |
svPPA (N=22) |
Total (N=171) |
p value |
η2 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | 56.8 (18.1) | 69.7 (7.5)** | 63.9 (9.1)* | 70.1 (10.4) * | 65.9 (9.7)* | 69.3 (6.4) * | 67.5 (7.3)* | 66.2 (7.4)* | 65.5 (10.5) | .0013 | .13 |
| Sex (M/F) | 11/8 | 7/5 | 37/19 | 13/5 | 19/6 | 5/11 | 6/7 | 8/14 | 98/79 | .14 | .06 |
| Education ◊ | 17.5 (3.4) | 16.2 (3.0) | 16.2 (2.8) | 15.9 (3.4) | 16.2 (2.5) | 17.1 (2.7) | 16.3 (2.4) | 15.7 (2.4) | 16.3 (2.8) | .49 | .05 |
| Global CDR® plus NACC FTLD score ◊ | 0.00 (0.00) | 1.29 (0.54) | 1.41 (0.60)† | 0.88 (0.37)† | 0.97 (0.35) | 0.89 (0.53)† | 1.33 (0.62) | 1.10 (0.49) | 1.21 (0.58) | .0016 | .17 |
| CDR® plus NACC FTLD Sum of Boxes ◊ | 0.0 (0.0) | 7.0 (2.8) | 7.5 (3.4)† | 4.6 (2.5)† | 5.6 (2.2) | 3.9 (2.8)† | 6.8 (3.0) | 5.8 (3.1) | 6.4 (3.4) | < .001 | .20 |
| MMSE total | 27.0 (NA) | 21.0 (5.7) | 24.2 (4.8) | 23.5 (5.7) | 20.0 (5.5)† | 26.3 (4.0)† | 24.6 (4.2) | 21.6 (5.6) | 23.2 (5.2) | .013 | .13 |
| BNT total ◊◊ | 10 (4.6) | 9.3 (3.2) | 12.1 (2.8) | 12.2 (3.7) | 8.9 (3.6) | 13.5 (1.8)* | 14.1 (1.1)* | 3.4 (3.0)** | 10.6 (4.4) | < .001 | 0.52 |
| SIVT total | 17.1 (0.5) | 15.5 (2.3) | 15.2 (3.3) | 15.4 (3.7) | 15.6 (2.1) | 15.9 (2.3) | 15.0 (3.8) | 14.3 (3.3)* | 15.3 (3.2) | .28 | .06 |
Abbreviations: AD = Alzheimer’s disease; bvFTD = behavioral variant frontotemporal dementia; CBS = corticobasal syndrome; lvPPA = logopenic variant primary progressive aphasia; nfvPPA = non-fluent variant primary progressive aphasia; PSP = progressive supranuclear palsy; svPPA = semantic variant primary progressive aphasia; NACC = National Alzheimer’s Coordinating Center: CDR plus NACC FTLD = CDR Dementia Staging Instrument plus Behavior and Language domains from the NACC Frontotemporal Lobar Degeneration Module. Analyses are controlled for age and sex if appropriate.
Different from normal controls at p <.05 using Dunnett-Hsu tests.
Different from normal controls at p <.001 using Dunnett-Hsu tests.
Different from other disease group(s) at p <.05 using Tukey-Kramer tests.
Different from other disease group(s) at p <.001 using Tukey-Kramer tests.
N = 26 missing.
17% missing data, MICE imputed